Product Name

Product Name

CAS

Structure

Chemical Name

Quality

Appearance

Assay

Single impurity

Nintedanib esylate

Nintedanib esylate

656247-18-6

nintedanib esylate；(3S,5S)-3,5-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-hydroxy-cyclohexanecarboxylic Acid Methyl Ester

Light yellow powder

>99%

<0.1%

NDNB-1

1160293-25-3

1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

white powder

>90%

<4.0%

NDNB-2

1174335-83-1

(E)-methyl 1-acetyl-3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate

Yellow solid

>90%

<4.0%

NDNB-3

1168150-46-6

(3E)-2,3-Dihydro-3-(methoxyphenylmethylene)-2-oxo-1H-indole-6-carboxylicacid methyl ester

Yellow solid

>95%

<5.0%

NDNB-4

656247-17-5

methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate Nintedanib (BIBF 1120)

Yellow solid

>99%

<1.0%